PEG-400 as an efficient and recyclable reaction medium for the synthesis of polyhydroquinolines via Hantzsch reaction

PEG-400 as an efficient and recyclable reaction medium for the synthesis of polyhydroquinolines via Hantzsch reaction

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Polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using PEG-400 as reaction medium.The Purse Fabrics present method does not involve any hazardous organic solvents or toxic catalysts.The present methodology offers several advantages such as simple procedure, excellent Pura Refill yields with shorter reaction times and purification of products by non-chromatographic methods.